Since 2003, more than 3,000 published cases of osteonecrosis of the jaw (ONJ) have been reported from taking bisphosphonates. While most of the cases involve cancer patients who take the intravenous versions of the drug; a few years ago, ONJ began turning up in healthy women taking Fosamax to increase bone density.
Most documented cases have been in people who have had a tooth extraction. (Read more about Fosamax ONJ)